Factors in the Success of the GCC Chemical Industry
ImmobilizationImmobilizing an enzyme can have interesting effects on its behaviour. It can lead to increased selectivity, stability or activity. Associating an enzyme with a solid support surrounds it with a new microenvironment which can restrict its movements and offer protection against harsh conditions.
Immobilization also eliminates the enzyme’s ability to aggregate, increasing the amount of enzyme which can be loaded into a reaction. For this reason, the potentialproductivity of biocatalytic processes that use immobilized enzymes is often higher than those that use enzymes free in solution.
- Covalent Bonding
International Regulations and the Supply Chain
Until the development of EziG (see below), there was no general method of immobilization that works for all enzymes. Each immobilization method that has beenestablished is an attempt to find a reliable and affordable technique that immobilizes the enzyme while retaining its catalytic activity. Immobilization methods differ from one another based on the properties of the material used for the solid support, the characteristics of the enzyme, and the conditions under which the immobilization process is conducted.
The method used to immobilize an enzyme will have some impact on the activity of the enzyme and given that each enzyme has unique characteristics, finding the right method for a particular process can be challenging. There are several general methods by which enzymes are immobilized: